Influence of Interfacial Force Models and Population Balance Models on the kLa Value in Stirred Bioreactors

Optimal oxygen supply is vitally important for the cultivation of aerobically growing cells, as it has a direct influence on cell growth and product formation. A process engineering parameter directly related to volumetric mass transfer coefficient kLa. It influences kLa computing time different interfacial force population balance models in stirred bioreactors that have been evaluated this study. For investigation, OpenFOAM 7 open-source toolbox was utilized. Firstly, Euler–Euler model with constant bubble diameter applied 2L scale bioreactor statistically examine value. shown kL greatest calculated To eliminate problem take effects such breakup coalescence into account, coupled (PBM). purpose, four five were examined. Ultimately, established that, all tested, coupling computational fluid dynamics (CFD) PBM resulted better agreement experimental data than using model. However, should be noted higher accuracy requires twice computation time.